Recent Trends in Nanoscience and Technology

Poly (Lactic Acid) Nano-structures for Cartilage Regeneration and Joint Repair: Strategies and Ideas

Author(s): Farnaz-Sadat Fattahi*

Cartilage repair and regeneration remain mainly obstinate owing to a very low regenerative potential of this tissue. The field of Cartilage Tissue Engineering, which is aimed to repair, regenerate, and improve injured or diseased cartilage functionality, has induced penetrating attention and grips inordinate possible for successful Cartilage-Therapy. Improvements in bio-material investigation and High-tech enhanced constructing of scaffolds have improved the productivity of Tissue-Engineering. Nano fibrous scaffolds mimic the native extracellular matrix of cartilage, offering a provision for cartilage tissue engineering through advancing Cell Viability, Cell Adhesion, Cell Propagation, Osteo-genic Isolation, Vascularization, Host Integration, and Load Bearing. Fabrication of these scaffolds with Poly Lactic Acid (PLA) Bio Polymer has permitted modified cartilage repair. PLA is effortlessly processable, degrades and degenerates to natural-metabolites. Consequently, the prospective of using PLA Nano fibers for cartilage repair is a thoughtful objective for researchers in new examinations. In this review, we deliberate the various methodologies applied in constructing PLA Nano-fibrous scaffolds for Cartilage Tissue Engineering. Also a general report of the present state and development in cartilage repair and regeneration by Poly Lactic Acid Nano-fibers will be delivered.